FRINGE PROTEINS MODULATE NOTCH-LIGAND CIS AND TRANS INTERACTIONS TO SPECIFY SIGNALING STATES

The Notch signaling pathway consists of multiple types of receptors and ligands, whose interactions can be tuned by Fringe glycosyltransferases.A major challenge is to determine how these components control the specificity and directionality of Notch signaling in developmental contexts.Here, we analyzed same-cell (cis) Notch-ligand interactions for

Pavement maintenance prioritization considering both quality and cost is an important decision-making problem.In this paper, the actual pavement condition index of city roads was calculated using municipal patrol data.A linear optimization model that maximized maintenance quality with limited maintenance costs and a multi-objective optimization mod